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          蟲草素LDH插層納米復合體


          【發布日期】:2004-11-16  【來源】:
          【核心提示】:IntercalativeNanohybrideofCordycepininLayeredDoubleHydroxideAbstract:Anovelnegativelychargedcordycepin-[M

          Intercalative Nanohybride of Cordycepin in Layered Double Hydroxide

          Abstract:A novel negatively charged cordycepin-[Mg-Al-NO] nanohybrid has been prepared by ion-exchanged method.Results of TEM, PXRD and FT-IR spectroscopy confirmed that cordycepin could be intercalated into [Mg-Al-NO3] interlayers as the charge-compensating species.Preliminary result show that the new bioinorganic nanohybrid may be used as a novel inorganic pharmaceutically active compounds reservoir or carrier.b.

          Keywords:cordycepin; layered double hydroxide; nanohybrid; intercalate

          蟲草素LDH插層納米復合體

          楊親正  羅珊珊  凌建亞  李彥  張長鎧 

          摘 要:通過離子交換反應制備了一種新型蟲草素層狀雙氫氧化物納米復合體. 透射電鏡、X-衍射和紅外光譜分析結果表明,帶負電的蟲草素中和無機層片電荷而插層到鎂鋁層狀雙氫氧化物[Mg-Al-NO3]中.實驗結果顯示,通過簡單的離子交換,可制得新型生物有機納米復合體,該類納米復合體將有可能成為生物活性分子的貯存庫或載體.

          關鍵詞:蟲草素; 層狀雙氫氧化物; 納米復合體; 插入

          CLC Number:S567.3+5

          Author Resume:Yang Qinzheng,mail,born in 1975,Ph.D..Address:State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100.張長鎧,Corresponding author

          Author Unit:楊親正(山東大學微生物技術國家重點實驗室,濟南,250100) 

               羅珊珊(山東大學微生物技術國家重點實驗室,濟南,250100) 

               凌建亞(山東大學微生物技術國家重點實驗室,濟南,250100) 

               李彥(山東大學微生物技術國家重點實驗室,濟南,250100) 

               張長鎧(山東大學微生物技術國家重點實驗室,濟南,250100) 

          References:

          [1]Xu Z P , Zeng H C.Abrupt structural transformation in hydrotalcite-like compounds Mg1-xAlx(OH)2(NO3)x*nH2O as a continuous function of nitrate anio.J Phys Chem B ,2001, 105: 1743.

          [2]Legrouri A , Badreddine M, Barroug A, et al. Influence of pH on the synthesis of the Zn-Al-nitrate layered double hydroxide and the exchange of nitrate by phosphate ions. J P Besse,J Mater Sci Lett,1999, 18:1077

          [3]Choy J H, Kwak S Y , Park J S, et al.Intercalative nanohybrids of nucleoside monophosphates and DNA in layered metal hydroxide. J Am Chem Soc,1999,121:1399

          [4]Zhao H T, Vance G F. Intercalation of carboxymethyl-cyclodextrin into magnesium-aluminum layered double hydroxide. J Chem Soc DaltonTrans,1997,11:1961

          [5]Ahn Y J, Park S J ,Lee S G , et al. Cordycepin selective growth inhibitor derived from liquid culture of cordyceps militaris against clostridium spp. J Agric Food Chem,2000, 48:2744

          [6]Suger A M ,Mccaffrey R P .Antifungal activity of 3'-deoxyadenosine (cordycepin). Agents Chemother, 1998, 42:1424

          [7]Mueller W E G, Weiler B E, R, Charubala Ret al.Cordycepin analogues of 2'5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochem Wash,1991, 30:2027

          [8]Grahn B , Loevtrup-Rein H .The effect of cordycepin on nuclear RNA synthesis in nerve and glial cells. Acta Physiol Scand,1971, 82:28

          [9]Yang Q Z , Zhan C G, Sun D J ,et al.Studies on Synthesis and Properties of Mg-Al-Nitrate Layered Double Hydroxide .Acta Chimica Sinica,2002, 9:1712

          [10]Ling J Y , Sun Y J, Zhang H,et al.Measurement of cordycepin and adenosine in stroma of cordyceps sp. By capillary zone electrophoresis.J BiosBioe, 2002, 94:371

          華中農業大學學報

          JOURNAL OF HUAZHONG AGRICULTURAL UNIVERSITY

          2004 Vol.23 No.1

           
           
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